Подборка материалов из научных журналов по лечению ревматических заболеваний методом лечебного голодания на разных языках.
Short-term therapeutic fasting in the treatment of chronic pain and fatigue syndromes - well-being and side effects with and without mineral supplements [Article in German].
Кратковременное лечебное голодание при лечении синдромов хронической боли и хронической усталости, побочных эффектов лекарственной терапии без применения минеральных пищевых добавок. Статья на немецком языке, резюме на английском.
CONCLUSIONS: Short-term fasting in patients with pain and stress syndromes is safe and well tolerated, concomitant mineral supplements have no additive benefit.
ВЫВОД: Кратковременное лечебное голодание пациентов с хронической болью и синдромом напряжения безопасно, хорошо переносится. Применение минеральных пищевых добавок не дает преимуществ.
Fasting followed by vegetarian diet in patients with rheumatoid arthritis: a systematic review.
Систематический обзор литературы по лечебному голоданию с последующим соблюдением вегетарианской диетой больных с ревматоидным артритом.
Effects of a low calorie vegan diet on disease activity and general conditions in patients with rheumatoid arthritis [Article in Japanese].
Эффекты низкокалорийной вегетарианской диеты на активность заболевания и общее состояние больных с ревматоидным артритом. Статья на японском языке, резюме на английском.
Changes in laboratory variables in rheumatoid arthritis patients during a trial of fasting and one-year vegetarian diet.
Динамика изменений лабораторных параметров у больных ревматоидным артритом во время контролируемых исследований влияния лечебного голодания и соблюдения вегетарианской диеты в течение года.
Controlled trial of fasting and one-year vegetarian diet in rheumatoid arthritis.
Контролируемые исследования лечебного голодания и соблюдения вегетарианской диеты при лечении ревматоидного артрита.
Резюме полностью.
Short-term therapeutic fasting in the treatment of chronic pain and fatigue syndromes--well-being and side effects with and without mineral supplements [Article in German].
Forsch Komplementarmed Klass Naturheilkd 2002 Aug;9(4):221-7.
Michalsen A, Weidenhammer W, Melchart D, Langhorst J, Saha J, Dobos G.
Abteilung fur Innere Medizin V, Naturheilkunde und Integrative Medizin, Kliniken Essen Mitte, Essen.
Fasting followed by vegetarian diet has shown to be an effective treatment for rheumatoid arthritis, moreover fasting is frequently used as an adjunctive treatment in chronic pain and stress/exhaustion syndromes. Data on well-being and the frequency of side effects during fasting are mostly retrospective. Mineral supplements are frequently used in order to compensate for fasting-induced tissue acidosis and to reduce side effects. There are only limited data that support this practice. OBJECTIVE: To study the effects of oral mineral supplements on common side effects and well-being during short-term fasting. PATIENTS AND METHODS: 209 consecutive inpatients with chronic pain/exhaustion syndromes were recruited. In a controlled non-randomised study design all patients underwent fasting (250 kcal; 3 l fluid intake/day) over 7 days, in study phase 1 without (n = 103) and in study phase 2 with (n = 106) concomitant prescription of standardised oral mineral supplements (3 x 2 to 3 x 3 Bullrich's Vital). Weight, blood pressure and urinary pH were recorded daily. Well-being and mood as well as common side effects (i.e. fatigue, hunger, heart burn, headache) were assessed with standardised self-reports. RESULTS: Baseline characteristics of the 209 patients (mean age 54.7 +/- 10.5 years; 83.3% female) were balanced. Both groups showed a fasting-induced decrease of blood pressure, a slight decrease in mood and well-being on days 3 and 4 with consecutive increase and moderate hunger, i.e. in the evening. Side effects and general tolerability of fasting as well as well-being and mood were not different between the groups. There were no serious side effects in both groups. CONCLUSIONS: Short-term fasting in inpatients with pain and stress syndromes is safe and well tolerated, concomitant mineral supplements have no additive benefit.
Fasting followed by vegetarian diet in patients with rheumatoid arthritis: a systematic review.
Scand J Rheumatol 2001;30(1):1-10.
Muller H, de Toledo FW, Resch KL.
Balneology and Rehabilitation Sciences Research Institute (FBK), Bad Elster, Germany.
Clinical experience suggests that fasting followed by vegetarian diet may help patients with rheumatoid arthritis (RA). We reviewed the available scientific evidence, because patients frequently ask for dietary advice, and exclusive pharmacological treatment of RA is often not satisfying. Fasting studies in RA were searched in MEDLINE and by checking references in relevant reports. The results of the controlled studies which reported follow-up data for at least three months after fasting were quantitatively pooled. Thirty-one reports of fasting studies in patients with RA were found. Only four controlled studies investigated the effects of fasting and subsequent diets for at least three months. The pooling of these studies showed a statistically and clinically significant beneficial long-term effect. Thus, available evidence suggests that fasting followed by vegetarian diets might be useful in the treatment of RA. More randomised long-term studies are needed to confirm this view by methodologically convincing data.
Effects of a low calorie vegan diet on disease activity and general conditions in patients with rheumatoid arthritis [Article in Japanese].
Rinsho Byori 1999 Jun;47(6):554-60.
Fujita A, Hashimoto Y, Nakahara K, Tanaka T, Okuda T, Koda M.
Clinical Research Laboratory, Sunstar Co. Ltd., Takatsuki.
There is little objective information about diet therapy for rheumatoid arthritis (RA) in Japan. We studied 14 patients with RA who stayed in the Koda hospital for 55 days. They basically took a 1200 kcal vegan diet consisting of unpolished rice gruel, juice of raw vegetables, soya bean curd and sesame seeds, and undertook a 3-5-day fast three times. During the 55-day stay, average body weight decreased by 5.1kg. Lansbury index and ESR decreased whereas CRP did not change. WBC decreased and the differential cell counts showed a decrease of neutrophils, eosinophils and monocytes without a change in lymphocytes or basophils. RBC, hemoglobin and MCV increased. LDL-C decreased, while HDL-C increased. There was no change in total protein or albumin. These data suggest that this combination of a low calorie vegan diet and fasting may contribute to improve RA with little undesirable effects on the patient's general conditions.
Changes in glycosylation of IgG during fasting in patients with rheumatoid arthritis.
Br J Rheumatol 1996 Feb;35(2):117-9.
Kjeldsen-Kragh J, Sumar N, Bodman-Smith K, Brostoff J.
Institute of Immunology and Rheumatology, The National Hospital, Olso, Norway.
Patients with rheumatoid arthritis (RA) have a higher proportion of agalactosyl IgG than healthy individuals. Glycosylation status was examined in 26 RA patients who fasted for 7-10 days and afterwards followed a vegetarian diet for 3.5 months. The decrease in the proportion of agalactosyl IgG correlated significantly with the clinical improvement after the fasting period, but not after the vegetarian diet period. Although the glycosylation status of IgG may have played a role in the improvement of disease during the fasting period, it did not seem to be associated with, and therefore responsible for, the clinical improvement observed after the vegetarian diet.
Changes in laboratory variables in rheumatoid arthritis patients during a trial of fasting and one-year vegetarian diet.
Scand J Rheumatol. 1995;24(2):85-93.
Kjeldsen-Kragh J, Mellbye OJ, Haugen M, Mollnes TE, Hammer HB, Sioud M, Forre O.
Institute of Immunology and Rheumatology, National Hospital, Oslo, Norway.
We have previously reported that significant improvement may be obtained in rheumatoid arthritis patients by fasting followed by a vegetarian diet for one year. The present study was carried out to examine to what extent biochemical and immunological variables changed during the clinical trial of fasting and vegetarian diet. For the patients who were randomised to the vegetarian diet there was a significant decrease in platelet count, leukocyte count, calprotectin, total IgG, IgM rheumatoid factor (RF), C3-activation products, and the complement components C3 and C4 after one month of treatment. None of the measured parameters changed significantly during this period in the group of omnivores. The course of 14 of 15 measured variables favored the vegetarians compared with the omnivores, but the difference was only significant for leukocyte count, IgM RF, and the complement components C3 and C4. Most of the laboratory variables declined considerably in the vegetarians who improved according to clinical variables, indicating a substantial reduction in inflammatory activity. The leukocyte count, however, decreased in the vegetarians irrespective of the clinical results. Thus, the decline in leukocyte count may be attributed to vegetarian diet per se and not to the reduction in disease activity. The results of the present study are in accordance with the findings from the clinical trial, namely that dietary treatment can reduce the disease activity in some patients with rheumatoid arthritis.
Controlled trial of fasting and one-year vegetarian diet in rheumatoid arthritis.
Lancet. 1991 Oct 12;338(8772):899-902.
Kjeldsen-Kragh J, Haugen M, Borchgrevink CF, Laerum E, Eek M, Mowinkel P, Hovi K, Forre O.
Department of General Practice, University of Oslo, Norway.
Fasting is an effective treatment for rheumatoid arthritis, but most patients relapse on reintroduction of food. The effect of fasting followed by one year of a vegetarian diet was assessed in a randomised, single-blind controlled trial. 27 patients were allocated to a four-week stay at a health farm. After an initial 7-10 day subtotal fast, they were put on an individually adjusted gluten-free vegan diet for 3.5 months. The food was then gradually changed to a lactovegetarian diet for the remainder of the study. A control group of 26 patients stayed for four weeks at a convalescent home, but ate an ordinary diet throughout the whole study period. After four weeks at the health farm the diet group showed a significant improvement in number of tender joints, Ritchie's articular index, number of swollen joints, pain score, duration of morning stiffness, grip strength, erythrocyte sedimentation rate, C-reactive protein, white blood cell count, and a health assessment questionnaire score. In the control group, only pain score improved score. In the control group, only pain score improved significantly. The benefits in the diet group were still present after one year, and evaluation of the whole course showed significant advantages for the diet group in all measured indices. This dietary regimen seems to be a useful supplement to conventional medical treatment of rheumatoid arthritis.
Rheumatoid arthritis (RA) or fibromyalgia (FM)
BMC Complement Altern Med. 2005 Dec 22;5:22
Mediterranean diet or extended fasting's influence on changing the intestinal microflora, immunoglobulin A secretion and clinical outcome in patients with rheumatoid arthritis and fibromyalgia: an observational study.
Michalsen A, Riegert M, Ludtke R, Backer M, Langhorst J, Schwickert M, Dobos GJ.
Kliniken Essen-Mitte, Department of Internal and Integrative Medicine, University Duisburg-Essen, am Deimelsberg 34a, 45276 Essen, Germany. .
BACKGROUND: Alterations in the intestinal bacterial flora are believed to be contributing factors to many chronic inflammatory and degenerative diseases including rheumatic diseases. While microbiological fecal culture analysis is now increasingly used, little is known about the relationship of changes in intestinal flora, dietary patterns and clinical outcome in specific diseases. To clarify the role of microbiological culture analysis we aimed to evaluate whether in patients with rheumatoid arthritis (RA) or fibromyalgia (FM) a Mediterranean diet or an 8-day fasting period are associated with changes in fecal flora and whether changes in fecal flora are associated with clinical outcome. METHODS: During a two-months-period 51 consecutive patients from an Integrative Medicine hospital department with an established diagnosis of RA (n = 16) or FM (n = 35) were included in the study. According to predefined clinical criteria and the subjects' choice the patients received a mostly vegetarian Mediterranean diet (n = 21; mean age 50.9 +/-13.3 y) or participated in an intermittent modified 8-day fasting therapy (n = 30; mean age 53.7 +/- 9.4 y). Quantitative aerob and anaerob bacterial flora, stool pH and concentrations of secretory immunoglobulin A (sIgA) were analysed from stool samples at the beginning, at the end of the 2-week hospital stay and at a 3-months follow-up. Clinical outcome was assessed with the DAS 28 for RA patients and with a disease severity rating scale in FM patients. RESULTS: We found no significant changes in the fecal bacterial counts following the two dietary interventions within and between groups, nor were significant differences found in the analysis of sIgA and stool ph. Clinical improvement at the end of the hospital stay tended to be greater in fasting vs. non-fasting patients with RA (p = 0.09). Clinical outcome was not related to alterations in the intestinal flora. CONCLUSION: Neither Mediterranean diet nor fasting treatments affect the microbiologically assessed intestinal flora and sIgA levels in patients with RA and FM. The impact of dietary interventions on the human intestinal flora and the role of the fecal flora in rheumatic diseases have to be clarified with newer molecular analysis techniques. The potential benefit of fasting treatment in RA and FM should be further tested in randomised trials.
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